WebMar 1, 2014 · Here, we show that cytosolic phospholipase A 2 ε (cPLA 2 ε, also known as PLA2G4E) is targeted to the membrane compartments of the clathrin-independent endocytic route through a C-terminal stretch of positively charged amino acids, which allows the enzyme to interact with phosphoinositide lipids [especially PI (4,5)P 2] that are enriched … WebMay 1, 2004 · Phospholipase A 2 type IVA (IVAPLA 2) is a cytosolic enzyme that on activation selectively releases arachidonic acid (AA) from cell membrane phospholipids.Both AA and lysophospholipid, products of the enzymic reaction, can function as signal transducers in cellular interactions. The enzyme is present in most cells, including …
Pivotal role of cytosolic phospholipase PLA2G4A in the …
WebSep 7, 2010 · Cytosolic phospholipase A2 alpha structure and activation. The binding of calcium (Ca 2+) ions to the CalB motif of the C2 domain promotes the translocation of cPLA 2 α from the cytosol to the perinuclear/membrane region of the cell. Following this change in subcellular localization, cPLA 2 α is phosphorylated on key serine residues of the … WebIncreased cytosolic phospholipase A2α (cPLA2α) immunoreactivity and transcript were observed in Alzheimer's disease (AD) brain associated with amyloid deposits. Thus, the … dalry community centre
Cytosolic Phospholipase A2 - an overview ScienceDirect Topics
WebJun 15, 2024 · Background Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease (AD), but the mechanisms for this association are not clear. The activation of calcium-dependent cytosolic phospholipase A2 (cPLA2) is involved in inflammatory signaling … WebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic … WebApr 16, 2024 · Calcium-dependent cytosolic phospholipase A 2 (cPLA2) releases arachidonic acid (AA, 20:4 n-6), which plays important functions in storing energy, as a second messenger in neurotransmission, and as the precursor of eicosanoids [ 4, 5 ]. dalry cemetery records