The pleiotropic benefits of statins

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August undefined, 2024

Webb7 apr. 2024 · Request PDF The pleiotropic effects of statins in rheumatoid arthritis Objectives: Rheumatoid arthritis (RA) is an inflammatory and autoimmune disease. Studies over the past two decades ... Webb22 juli 2024 · As a result of their pleiotropic effects statins modulate virtually all known processes of atherosclerosis and have beneficial effects outside the cardiovascular …

Pleiotropic Effects of Statins: Lipid Reduction and Beyond

WebbAlong with lipid-lowering potency, the beneficial pleiotropic effects of statins, such as the antibacterial and immunomodulatory properties, may act in a dose-dependent fashion. … WebbBeneficial Cardiovascular Pleiotropic Effects of Statins Jean Davignon, MD Abstract—Pleiotropic effects of a drug are actions other than those for which the agent … dvd backup copy

Statin Utilization Trend in Primary and Secondary Prevention of ...

Webb7 nov. 2024 · Ultimately, the benefits of statins in an infection setting appear to require attention to the underlying host response and to the timing of the dosage. From this examination of statin efficacy, additional novel host-directed strategies may produce adjunctive therapeutic approaches for the treatment of infection where traditional … Webb6 jan. 2024 · The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol … Webb1 feb. 2015 · The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. The concept of lipoproteins as lipid transporters has evolved to encompass functions in coagulation, inflammation, and redox reactions due to their unique protein cargo. dvd backup copy software

Open access Protocol Statins for extension of disability-free …

Focus on Statins: Lipid-Lowering Mechanisms and Beyond

WebbPitavastatin has been shown to have similar pleiotropic effects to other statins, including decreasing platelet activation and improving cardiac and endothelial function. 32 Thus, it … Webbför 6 timmar sedan · select article The pleiotropic effects of high-density lipoproteins and apolipoprotein A-I. https: ... select article The advantages and pitfalls of genetic analysis in the diagnosis and management of lipid disorders. ... Statins and diabetes: What are the connections? Naveed Sattar. Article 101749 View PDF. dvd back and front coverWebb3 mars 2024 · Despite effective lipid reduction and corresponding benefits for cardiovascular disease prevention and treatment, statins have pleiotropic effects potentially increasing the risk of ischemic heart ... in as much as synonyms

"Webb17 sep. 2015 · “Pleiotropic" effects of statins involve improving endothelial function, decreasing vascular inflammation and oxidative stress, and inhibiting the thrombogenic … " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

Statins in acute coronary syndrome: Ther Adv Cardiovasc Dis very …

WebbThis paper builds on these findings and presents practical guidance for maximising the pleiotropic benefits of this class of medicines in people with T2DM in terms of reducing adverse CVD outcomes. The Improving Diabetes Steering Committee aims to offer evidence-based practical guidance for the use of SGLT2i therapies in people with T2DM … WebbDespite the progressions in COVID-19 understanding, the optimization of patient-specific therapies remains a challenge. Statins, the most widely prescribed lipid-lowering drugs, …

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Webb12 juni 2015 · This finding “suggests that reduction of LDL cholesterol levels per se explains the effect of statins on coronary heart disease,” rather than some pleiotropic benefit specific to statins, the editorialists wrote. “It’s nice to have all the different options for patients,” Cannon said. Webb1 apr. 2002 · These agents appear to reduce bone fractures and may improve insulin sensitivity and reduce the likelihood of persons progressing from impaired glucose …

WebbIn RA patients, the risk of CVD is reduced by statin treatment, and statin discontinuation is associated with an increased cardiovascular disease risk. Summary: The combined …

WebbHowever, it is not clear that the purported effectiveness of statins in neurodegenerative disorders is directly related to cholesterol-lowering effects of these agents; rather, the pleiotropic functions of statins likely play critical roles. Moreover, it is becoming more apparent with… Visualizza altro WebbConcerns about the hazards of statins on the development and mortality of stomach cancers remain controversial. Here, we investigated the likelihood of incident gastric cancers and related mortality depending on statin exposure, statin type, and the duration of use. This nested case–control-designed study was composed of 8798 patients who …

WebbIndeed, recent studies indicate that some of the cholesterol-independent or “pleiotropic” effects of statins involve improving endothelial function, enhancing the stability of …

Webb17 okt. 2024 · However, the clinical benefit of statin-induced elevation of HDL-cholesterol is unclear from trial data, ... statins have pleiotropic benefits including prevention of LDL oxidation. View full-text. in as much as lies within you be at peaceWebb27 okt. 2016 · Individualized Statin Benefit for Determining Statin Eligibility in the Primary Prevention of Cardiovascular Disease. Circulation. 2016 Apr 19;133(16):1574-81. Robinson JG, Ray K. Moving Toward the Next Paradigm for Cardiovascular Prevention. Circulation. 2016 Apr 19;133(16):1533-6. in as much as it is to you live at peaceWebb22 apr. 2024 · More than 35 million Americans take statins, most of whom are prescribed Atorvastatin being one of the most popular prescription drugs of its kind. Here are some of the many benefits of taking Atorvastatin medication for patients:. Taking Atorvastatin benefits the body’s cholesterol levels.; Atorvastatin works primarily by reducing low … dvd backup software for windows 7Webb10 mars 2015 · In summary, statins are probably both under- and over-utilized in older adults. For example, it is estimated that only 40-60% of patients over 65 are prescribed a statin after an acute MI; 24 conversely, a recent study found that 30% of patients with a cancer diagnosis were dispensed a statin within 30 days of dying. 25 For primary … dvd bad sectorsWebb15 maj 2024 · Statins also impart a modest benefit in concentrations of triglycerides, high-density lipoproteins (HDL) and very low-density lipoproteins (VLDL). 2 Moreover, statins exert pleiotropic effects such as improvement of endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and … in as much as fayetteville ncWebb13 apr. 2016 · PDF On Apr 13, 2016, Kirk Pappan published Why HMG Could be the Signal Responsible for the Pleiotropic Effect of Statins Pleiotropic Find, read and cite all the research you need on ResearchGate dvd backup software for vistaWebb1 maj 2024 · The so-called pleiotropic effects are mediated by the reduction of isoprenoids, such as farnesyl-pyrophosphate and geranylgeranyl-pyrophosphate, necessary for the activation of small GTPases like Rho and Ras proteins (Fig. 1A).Statins diversely inhibit RhoA and Rac1 prenylation, modulating endothelial nitric oxide (NO) synthase … dvd backyardigans completo